Human disease resulting from gene mutations that interfere with appropriate nuclear factor‐κB activation
Identifieur interne : 008359 ( Main/Exploration ); précédent : 008358; suivant : 008360Human disease resulting from gene mutations that interfere with appropriate nuclear factor‐κB activation
Auteurs : Jordan S. Orange [États-Unis] ; Ofer Levy [États-Unis] ; Raif S. Geha [États-Unis]Source :
- Immunological Reviews [ 0105-2896 ] ; 2005-02.
Abstract
Summary: The nuclear factor (NF)‐κB family of transcription factors serves vital roles in a wide array of cell functions. An increasing number of human genetic lesions that result in defined disease entities are linked to inappropriate activation of NF‐κB. The resulting aberrant NF‐κB function can lead to cellular defects that ultimately impair normal developmental processes, host immune defenses, or both. Molecular defects that lie upstream in cell‐signaling pathways and rely upon NF‐κB activation tend to give a more specific phenotype, whereas those closer to the actual NF‐κB proteins have broader defects. A detailed study of these diseases can provide insight into the biochemistry of NF‐κB activation as well as the role of NF‐κB in human health.
Url:
DOI: 10.1111/j.0105-2896.2005.00221.x
Affiliations:
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Orange</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Immunology, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Levy, Ofer" sort="Levy, Ofer" uniqKey="Levy O" first="Ofer" last="Levy">Ofer Levy</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Children's Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Geha, Raif S" sort="Geha, Raif S" uniqKey="Geha R" first="Raif S." last="Geha">Raif S. Geha</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Immunology, Children's Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Immunological Reviews</title><title level="j" type="alt">IMMUNOLOGICAL REVIEWS</title><idno type="ISSN">0105-2896</idno><idno type="eISSN">1600-065X</idno><imprint><biblScope unit="vol">203</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="21">21</biblScope><biblScope unit="page" to="37">37</biblScope><biblScope unit="page-count">17</biblScope><publisher>Munksgaard International Publishers</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-02">2005-02</date></imprint><idno type="ISSN">0105-2896</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0105-2896</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Summary: The nuclear factor (NF)‐κB family of transcription factors serves vital roles in a wide array of cell functions. An increasing number of human genetic lesions that result in defined disease entities are linked to inappropriate activation of NF‐κB. The resulting aberrant NF‐κB function can lead to cellular defects that ultimately impair normal developmental processes, host immune defenses, or both. Molecular defects that lie upstream in cell‐signaling pathways and rely upon NF‐κB activation tend to give a more specific phenotype, whereas those closer to the actual NF‐κB proteins have broader defects. A detailed study of these diseases can provide insight into the biochemistry of NF‐κB activation as well as the role of NF‐κB in human health.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Orange, Jordan S" sort="Orange, Jordan S" uniqKey="Orange J" first="Jordan S." last="Orange">Jordan S. Orange</name></region><name sortKey="Geha, Raif S" sort="Geha, Raif S" uniqKey="Geha R" first="Raif S." last="Geha">Raif S. Geha</name><name sortKey="Geha, Raif S" sort="Geha, Raif S" uniqKey="Geha R" first="Raif S." last="Geha">Raif S. Geha</name><name sortKey="Levy, Ofer" sort="Levy, Ofer" uniqKey="Levy O" first="Ofer" last="Levy">Ofer Levy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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